In order to make both PRP and PRF, your blood sample is spun at a high speed, allowing heavier components of your blood to sink to the bottom of the container, while lighter platelets and plasma stay at the top. This process makes it easier to extract only the platelets and plasma — or PRP.
PRF is processed at a slower speed. As a result, the finished product still retains some white blood cells, stem cells, and of course, fibrin. That means there are more carrying healing factors in PRF — specifically, factors associated with platelets, fibrin, and stem cells. The slower speed also has the potential to cause less damage to individual cells, which is especially important when harvesting stem cells for healing.